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Showing posts from August, 2017

LXR, PPARs, Oxysterols and CYP27A1

In our previous post we discussed about the potential importance of Myosins, TAM Receptors and their connection with Phagocytosis and Endoplasmic Reticulum Stress to the Syndromes discussed in this Blog.  In this post we will hypothesize as to why the LXR Receptor and several other topics (CYP27A1, Oxysterols, PPARG╬▒, PPAR╬│, LXR) appear in the Network Analysis graph.
You can see how Network Analysis identifies LXR as being important by placing the node close to the center of the Network :



You may also find the Nodes named ppargamma, pparalpha, ,oxysterols and cyp27a1 (CYP27A1 was not previously shown in any Network Analysis)in the diagram below :




According to [1], regarding PPARs and LXR :


"Peroxisome proliferator-activated receptors (PPARs) and (liver X receptors) LXRs are ligand-activated transcription factors that control lipid and glucose metabolism, as well as the inflammatory response. Because the macrophage plays an important role in host defense and immuno-inflammatory p…

New findings : Myosin, D3, Actins, Autophagy/Phagocytosis

It is time to look at some new findings as these were identified by Machine Learning and Network Analysis.
Before continuing please note that in previous posts we discussed the importance of Endoplasmic Reticulum Stress, the Unfolded Protein Response and Genes AXL, GRB2, MGP, TYRO3, MERTK, GGCX, GAS6, SH2B3.
Recall also that Sulfation has been also selected as important.

The latest findings suggest the following Topics as being relevant to the Research presented in this Blog :
CYP27A1 and VDBP LXR (Liver X Receptor ) Actins (G-Actin, F-Actin) Myosin Phagocytosis / Autophagy

On the following algorithmic run, Machine Learning identifies relevant Topics to this Research :