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Milk Fat Globule-EGF Factor 8 and MFGM

Moving forward to Medical Topics most likely related to ME/CFS and all syndromes discussed in the first post of this blog, it is now time to focus on Milk-Fat Globule Membrane (MFGM), Gene name MFGE8.

According to Wikipedia [1] :

Milk fat globule membrane (MFGM) is a complex and unique structure composed primarily of lipids and proteins that surrounds milk fat globule secreted from the milk producing cells of humans and other mammals. It is a source of multiple bioactive compounds, including phospholipids, glycolipids, glycoproteins, and carbohydrates that have important functional roles within the brain and gut.
Machine Learning suggests a very high importance of Milk-Fat Globule Membrane and MFGE8. I believe there are a number of reasons for this. It appears that MFGE8  has several positive qualities that are beneficial for Phagocytosis and apoptotic cell clearance, Inflammation, Autoimmunity and Intestinal Barrier Integrity to name a few. Here are some excerpts from [2,3] :
Intestinal…
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Extracellular Vesicles

It was quite interesting to see more from the work of Maureen Hanson , Professor at University of Cornell [1]. In her Webpage -at the moment of Writing- Extracellular Vesicles (EVs) are being mentioned as one of her Current Research projects. More specifically it is stated that :
"Another project aims to identify differences in gene expression and cargo of extracellular vesicles at baseline and following exercise in healthy and in subjects diagnosed with ME/CFS"


I will visit EVs later in the post.


 A paper of great interest by Professor Hanson is [2]. In this paper we read the following :


"Primary bile acids such as sulfoglycolithocholate (13) are synthesized in the liver and the major bile salts result from its conjugation with taurine (28) and glycine, forming taurochenodeoxycholate and glycochenodeoxycholate (21), respectively, which are all numbered metabolites found to be significantly reduced in ME/CFS patients. Reduction in these compounds is suggestive of damage …

Latest Network Analysis Results

I would like now to present the latest results as these where found using Network Analysis. The Network Analysis graph that has been presented so far was generated on April 2017. Since then many more topics were added and considered using both Network Analysis and Machine Learning Techniques.
Before continuing, please read the following Disclaimer :

The information discussed in this Blog and this Post is purely informational and does not constitute any Medical Advice of any Kind. If you are a patient do not take any chances with your Health. Talk to a Certified Health Professional.

The Network Analysis Graph (of which a specific area is shown) looks as follows :



From the Network Analysis we may hypothesise the following :

-The potentially  important roles of NAD (Nicotinamide Adenine Dinucleotide)  and Tocotrienol. The reason for which Tocotrienol is considered important requires further Research.
-The central roles of Flavoproteins and particularly FMN (Flavin Mononucleotide)
-The impor…